Apply every night to clean, dry skin on the face, neck and décolleté before applying the cream. The pack includes tools on the lower flap to facilitate the opening, application and preservation of the product. The pack includes tools on the lower flap to facilitate the opening, application and preservation of the product. 1. Proceed to open the vial with the help of the opener piece that is provided at the base of the product pack. Place on the neck of the ampoule and break. 2. On the neck of the open vial, place the teat, remove the cap, place it upside down and press the body of the teat to modulate the output of the product. Apply to previously clean and dry skin before the usual treatment mesoestetic® cream. Spread over face, neck and décolleté and massage until completely absorbed. It can be applied day or night. 3. Once the application is finished and if you have leftover product, put the cap back on the teat, and place it on the fastening base provided in the pack.